We found that treating MCF-7 or MDA-MB-231 cells with TAM and tranilast as a single treatment for 48 h significantly decreased TGF-β1 secretion from breast cancer cell lines, compared to control (p=0.21 for TAM and p < 0.01 for tranilast in MCF-7; p=0.26 for TAM and p < 0.05 for tranilast in MDA-MB-231 cells). The gene discussed is TGFB1; the disease is breast carcinoma.