Further, Ccl-12 and Cxcr-4 that were both shown to be involved in pulmonary fibrosis, Ccl-3 which has been described to be important in systemic sclerosis, and Ccr-2 that is associated with allograft fibrosis, were overexpressed[9, 30–33]. This evidence concerns the gene CXCR4 and pulmonary fibrosis.