We observed superior tumor accumulation with [89Zr]DFO-Ab2 compared to [89Zr]DFO-IgG with tumor uptake of 1.5 ± 0.42 %ID/g (p = 0.0006) at 7 days p.i. These results further support the specificity of [89Zr]DFO-Ab2 for LAT1 in vivo. Here, SLC7A5 is linked to neoplasm.