Since we observed a negative correlation between PTEN and MMP7 levels in both tumor samples from patients and in TNBC cell lines, we tried to understand the mechanistic relationship between PTEN and MMP7 by pharmacologically mimicking the PTEN’s presence by treating the cells with a pan PI3K inhibitor, LY294002 in MMP7 expressing MDA-MB468 TNBC cells. This evidence concerns the gene MMP7 and neoplasm.