Although WP deregulation (via expression of Wnt-ligands, or secreted Wnt antagonists or APC inactivation) have been observed in BC [14], the mechanism of WP-activation in different BC subtypes as well as its association with the clinical outcome in BC still remains either rudimentary or a matter of controversy since confirmatory reports relating to the mechanism of WP’s involvement in breast tumorigenesis had been mostly obtained from mouse models [15]. The gene discussed is APC; the disease is breast cancer.