The observed localization of higher levels of the active (dephosphorylated) beta-catenin in the nucleus of MDA-MB231 TN breast cancer cells may indicate that the nuclear/cytosolic ratio of beta-catenin can be more accurately associated with the state of activation of the WP (data not shown), and to the outcome in TNBC patients [19]. Here, CTNNB1 is linked to breast cancer.