ESR1 and breast carcinoma: Our report agrees with their results wherein they revealed that a lack of or a reduction of beta-catenin membrane expression and/or nuclear accumulation were significantly associated with estrogen receptor negativity, absence of HER2 gene amplification, lack/reduction of E-cadherin expression and tumors of the TN and basal-like phenotype, indicating that WP activation is preferentially found in TN/basal-like breast carcinomas, and is associated with poor clinical outcome.