DPA activates RXRG[41], a member of the retinoid X receptor family that is involved in mediating the anti-proliferative effects of retinoic acid and is down-regulated in several types of human cancers, including lung cancer [42]; DPA also activates cysteine-aspartic acid protease (Caspase) family members, which are involved in cancer cell apoptosis [43]. The gene discussed is RXRG; the disease is lung cancer.