Figure 5 indicates that the expression of pAkt decreased significantly in ChoPlas-induced CRBH-7919 proliferation inhibition. Since Akt is a major mediator of cell survival through the direct inhibition of Bcl-2 family members, further apoptosis in ChoPlas-treated hepatoma cells was detected by measuring Bcl-2 protein expression. Figure 5 shows that Bcl-2 expression decreased significantly in ChoPlas-induced CRBH-7919 proliferation inhibition. The gene discussed is AKT1; the disease is hepatocellular carcinoma.