Our results showed that expression of Snail, MMP-2 and MMP-9 but not Slug is up-regulated in the prostate cancer sections derived from PC3 and LAPC-4 cells overexpressing TIMP-1 when compared to the sections derived from the control PC3 and LAPC-4 cells (Figure 4). The gene discussed is SNAI2; the disease is Familial prostate cancer.