We found that TIMP-1 significantly promoted proliferation of prostate CAF but not that of prostate cancer cells (Figure 6 A-C) and that TIMP-1 significantly enhanced motility of these CAFs (Figure 6D), suggesting that the TIMP-1-mediated accumulation of prostate CAFs is likely resulted from both enhanced infiltration and expansion of prostate CAFs within the tumors. Here, TIMP1 is linked to Familial prostate cancer.