As a model to mimic the clinical features of SQM in human patients, Aire KO mice spontaneously develop CD4+ T cell-mediated autoimmune disease that provokes severe KCS (Figure 1B, middle) with progressive keratinization and corneal opacification (Figure 1B, right) noted by 8 - 10wks of age [6,9]. The gene discussed is CD4; the disease is autoimmune disease.