SLCO1B1 and neoplasm: However, previous studies have demonstrated that rs2306283 (A > G) may have little impact on SLCO1B1 activity [33,34] and no statistical significance was reported between rs2306283 and AUCSN38 or tumor response in 81 lung cancer patients[35], while the C allele of rs4149056 leads to decreased membrane expression of SLCO1B1, decreased transport activity, reduced drug clearance[36-39] and a higher plasma AUCSN38 in lung cancer patients[35].