A SLCO1B1 single-nucleotide polymorphism (SNP), rs4149056 (521T>C), has been demonstrated to be associated with a higher area under the concentration-time curve of SN38 (AUCSN38) and grade ≥ 3 neutropenia in lung cancer patients treated with irinotecan and cisplatin[15-17]. This evidence concerns the gene SLCO1B1 and lung cancer.