Recent whole exome sequencing study revealed that homozygous splicing mutation in NSUN2 to be a cause of Dubowitz-like syndrome, an autosomal recessive disorder characterized by the constellation of mild microcephaly, growth and mental retardation, eczema and peculiar facies [31]; The ADAMTS16 gene has been reported to play a role of the metalloproteinase in murine genitourinary development [32], and loss-of-function mutations of the MED10 gene have been previously linked with WNT/GSK3β/β-Catenin pathway function [33]. The gene discussed is ADAMTS16; the disease is microcephaly.