RUNX2 and breast cancer: All the SNPs that were found to be associated with breast cancer are located in intron 2 of the gene; the risk allele of rs2981578, a SNP that was identified in this study, created a putative binding site for Oct-1/Runx2, which gives rise to a strong protein-DNA complex that alters binding of the transcription factor and causes differential expression between the common and minor haplotypes of FGFR2[42].