In addition to the two aforementioned loci, we validated a total of 67 loci that were previously reported the association with breast cancer and identified six additional loci (rs4415084 of 5p12/MRPS30, rs6557161 of 6q25/ESR1, rs7465364 of 8p21/RPL17p33, rs672888 of 8q24/MYC, rs10509168 of 10q21/ZNF365 and rs17221259 of 12p13/ATF7IP) to have suggestive association (P<0.05) with breast cancer in Japanese population. The gene discussed is ESR1; the disease is breast cancer.