CDKN2B and coronary artery disorder: Briefly, A single nucleotide polymorphism (rs3217989) corresponding to cyclin-dependent kinase inhibitor-2B (CDKN2B) in the 9p21 region was protective against incident CAD in a sample of 548 African Americans [OR = 0.19, 95% CI = 0.07–0.50, p = 0.0008, a finding that was further replicated in a larger combined sample of 990 African Americans (Kral et al., 2011)].