Ccl2 mRNA expression has recently been shown to increase in all forms of AMD (Newman et al, 2012) and the CCL2/CCR2 axis is implicated in pathological inflammation and photoreceptor degeneration in chronic photo-oxidative stress (Suzuki et al, 2012), in carboxyethylpyrrole-immunization-induced retinopathy (Cruz-Guilloty et al, 2013), and in a model of retinitis pigmentosa (Guo et al, 2012). Here, CCL2 is linked to retinitis pigmentosa.