CX3CR1 and retinal degeneration: Compared to other models in which subretinal inflammation occurs secondarily to light-injury or genetic defects (Cruz-Guilloty et al, 2013; Guo et al, 2012; Kohno et al, 2013; Rutar et al, 2012; Suzuki et al, 2012), the Cx3cr1 knockout mouse model presents a primary MP accumulation in the absence of an inherited retinal degeneration (C57BL/6J background) (Combadiere et al, 2007).