The neuroprotective effect of inhibiting monocyte recruitment (via CCL2/CCR2 deletion or circulating monocyte depletion) in models of photoreceptor degeneration such as photo-oxidative stress (Rutar et al, 2012; Suzuki et al, 2012), the Abca4−/−Rdh8−/− mouse Stargardt/AMD model (Kohno et al, 2013), and in a carboxyethylpyrrole immunization induced AMD model (Cruz-Guilloty et al, 2013), seem to confirm this observation, while the role of monocyte recruitemnt in rd1 mice remains a point of controversy (Guo et al, 2012; Sasahara et al, 2008). The gene discussed is ABCA4; the disease is age-related macular degeneration.