Increased urinary and intraocular CCL2 levels have been found in patients with wet AMD (Guymer et al, 2011; Jonas et al, 2010; Newman et al, 2012), CCL2 is induced in murine CNV (Yamada et al, 2007), and CNV is reduced in Ccr2−/− and Ccl2−/− mice (Luhmann et al, 2009; Tsutsumi et al, 2003). This evidence concerns the gene CCL2 and wet macular degeneration.