IFNG and neoplasm: Whereas IFN-α/β primarily exerts its effects on macrophages, DCs, and NK cells by facilitating their activation and maturation and by enhancing their capacity to induce adaptive immune responses (Dunn et al. 2006), IFN-γ directly affects the tumor via inhibition of tumor cell proliferation, apoptosis induction, inhibition of angiogenesis, and an overall enhancement of tumor immunogenicity (Dunn et al. 2006; Lugade et al. 2008; Reits et al. 2006).