Upon infection with Sendai virus, IRF3 undergoes deglutathionylation by the cytoplasmic enzyme, glutaredoxin-1 (GRX-1); it becomes phosphorylated, homodimerizes, translocates to the nucleus, binds to target genes and activates transcription by interacting with CBP/p300 co-activators. This evidence concerns the gene GLRX and infection.