Although glucose intolerance, glucose to insulin ratio, and plasma insulin were greater in obese vs. lean rodents (Table 2; Genotype, P = 0.017, P = 0.0003, and P = 0.0057, respectively), there was no significant effect of diet on these variables (Diet, P = 0.35, P = 0.28 and P = 0.25, respectively). The gene discussed is INS; the disease is Glucose intolerance.