HIF-1 will subsequently bind to the hypoxia response elements to regulate transcription of over 100 target genes which favors tumor growth and metastasis, including vascular endothelial growth factor (VEGF) as well as genes that regulate cellular processes such as energy metabolism, cell proliferation, vascular development and remodelling, as well as vasotone [2,7,26]. Here, VEGFA is linked to neoplasm.