SOCS3 and chronic obstructive pulmonary disease: While online PCR for the two molecules SOCS-4 and SOCS-5 did not reveal a significant expression difference, the expression level of SOCS-3 significantly differed between the two groups of COPD and control tissues: In controls, the δδ-Ct-values of SOCS-3 mRNA expression was −3,99325 +/− 1,525749 indicating a high level of gene expression.