Malfunction of the Hpo signaling pathway and aberrant expressions of SWI/SNF chromatin-remodeling proteins BRM and BRG1 have been documented in a wide variety of human cancers including colorectal carcinoma (Reisman et al., 2009; Pan, 2010; Watanabe et al., 2011). Here, SMARCA4 is linked to colorectal carcinoma.