To investigate the diagnostic abilities of serum GP73 and AFP for HCC, Zhou et al performed a diagnostic meta-analysis with the following results: Sensitivity, 76 (95% CI, 51–91%) vs. 70% (95% CI, 47–86%) and specificity, 86 (95% CI, 65–95%) vs. 89% (95% CI, 69–96%), respectively, This indicated that serum GP73 has a comparable accuracy to AFP for the diagnosis of HCC (8). Here, AFP is linked to hepatocellular carcinoma.