Therefore, in the present study, the RNAi technique was used to inhibit nm23-H1 gene expression in the K562 cell line to investigate the affects of nm23-H1 gene expression on the proliferation and migration of the K562 cells and to further clarify its correlation with prognosis for the molecular targeted treatment of CML. The gene discussed is NME1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.