VEGFA and renal cell carcinoma: Thirdly, the result from the VEGF gene −2549I/D polymorphism exhibited a non-significant trend for an increased RCC risk in the DD vs. II, DI vs. II, DI+DD vs. II and DD vs. II+ID genetic models; however, the D allele was significantly associated with an increased RCC risk (OR, 1.62; 95% CI, 1.04–2.53; P=0.03).