In 2002, Abe et al(15) investigated the association between single nucleotide polymorphisms in the 3′-untranslated region (UTR) of the VEGF gene and RCC in the Japanese population, and indicated that the C702T, C936T and G1612A polymorphisms in the 3′-UTR of the VEGF gene are not associated with the risk of RCC. This evidence concerns the gene VEGFA and renal cell carcinoma.