WWOX and familial pancreatic carcinoma: Iliopoulos et al(38) studied the WWOX promoter methylation status in pancreatic cancer and reported methylation in region −148 to −37, respective to the transcription initiation site (+1), in pancreatic adenocarcinomas; the WWOX promoter methylation status was associated with its expression and following treatment with 5-aza-deoxycytidine in Hs766T cells, WWOX was expressed again.