CXCL12 and colorectal cancer: The enhancing effect of SDF-1 on cell proliferation was markedly inhibited by AMD3100 treatment in colorectal cancer cells (SW480), but AMD3100 alone did not significantly affect cell proliferation when compared with the results observed in the SDF-1 unstimulated group, which indicated that there was no autocrine growth stimulatory loop in the cell line (27).