In our previous study, it was demonstrated that hTERTC27 carried by adenovirus is able to augment the concentration of interleukin-2 (IL-2) and interferon-γ (IFN-γ) and induce antigen-specific cytotoxic T lymphocytes (CTLs) against glioma cells in vitro, indicating that adenovirus-delivered hTERTC27 may prolong survival time and inhibit the growth of glioma-bearing mice (14). Here, IL2 is linked to glioma.