The roles of PPAR-γ, COX-2 and p-IκB-α (important molecular targets for colon cancer chemoprevention) in stromal remodeling were investigated by comparing the expression of these molecules in the tumor and surrounding normal colonic mucosa of stromal myofibroblasts, macrophages and endothelial cells. The gene discussed is NFKBIA; the disease is malignant colon neoplasm.