MKI67 and neoplasm: A major finding of the present study is that the level of 3H-FLT uptake diffusely and significantly increased following the treatment with sorafenib compared with the control groups (Figs. 3 and 4A), even though the Ki-67-positive cell distribution, Ki-67 labeling index and tumor volume did not display significant changes between the sorafenib-treated and control groups (Figs. 2, 3 and 4B).