A study has shown that miR-34 is able to impair cell growth, cause the accumulation of the cells in the G1 phase, increase caspase-3 activation and more significantly, inhibit tumorsphere formation and growth, indicating that the restoration of the tumor-suppressor, miR-34, may provide a novel molecular therapy for p53-mutant gastric cancer (106). The gene discussed is TP53; the disease is neoplasm.