The data showed that P27Kip1 expression varied between carcinomas, and that when patients were divided into two groups according to miR-222 expression, the patients with high miR-222 expression levels presented with significantly lower P27Kip1 mRNA expression compared with patients with low miR-222 expression levels (P<0.01; Fig. 4B). The gene discussed is CDKN1B; the disease is carcinoma.