The LH levels of amenorroeic females with various aetiologies of cirrhosis were shown to have decreased below the normal range in 50% of patients with alcoholic cirrhosis and 42% of patients with non-alcoholic cirrhosis, and tests revealed that the hypothalamus, rather than the pituitary, was the site of the disturbance in gonadotrophin secretion (6). Here, PLOD1 is linked to alcoholic liver cirrhosis.