A previous genome-wide association study (GWAS) in RCC cases and controls of European background revealed that two loci mapped to EPAS1, encoding hypoxia inducible factor (HIF)-2α, on 2p21 (rs11894252 and rs7579899), a locus on 11q13.3 (rs7105934) and a locus mapped to SCARB1, encoding the scavenger receptor class B, member 1, on 12q24.31 (rs4765623) were significantly associated with RCC susceptibility (20). Here, SCARB1 is linked to renal cell carcinoma.