With regard to the clinicopathological factors, a significant correlation was demonstrated between high BMP8B mRNA expression in the bone marrow and the diffuse type (P=0.009), lymph node metastasis (P=0.009), liver metastasis (P=0.044) and peritoneal dissemination (P<0.001) of the tumors (Table II). This evidence concerns the gene BMP8B and metastasis.