Compared with RSCC, six genes were downregulated in LSCC; UBD, C20orf35, SYT13, ZNF560, PLEKHB2 and FCGBP. Yan et al demonstrated that UBD may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator that may predict tumor recurrence in stage II and III patients following curative surgery (20). Here, PLEKHB2 is linked to neoplasm.