TLR4 and digestive system neoplasm: The authors identified that a genetic deletion model of TLR4 (Apoe−/−/TLR4−/−) led to a reduction in high-fat, high-cholesterol diet-induced liver inflammation and injury compared with that observed in wild-type mice (Apoe−/−/TLR4+/+), which is associated with the reduced expression of ROS and pro-inflammatory cytokines.