The results of the meta-analysis revealed that the BACH1 919Ser polymorphism was correlated with a decreased risk of breast cancer (Ser allele versus Pro allele: OR=0.91, 95% CI=0.87–0.96, P<0.001; Pro/Ser + Ser/Ser versus Pro/Pro: OR=0.92, 95% CI=0.86–0.99, P=0.022; Ser/Ser versus Pro/Pro + Pro/Ser: OR=0.83, 95% CI=0.76–0.92, P<0.001; Ser/Ser versus Pro/Pro: OR=0.81, 95% CI=0.73–0.90, P<0.001; Ser/Ser versus Pro/Ser: OR=0.85, 95% CI=0.77–0.94, P=0.001). This evidence concerns the gene BACH1 and breast carcinoma.