NLRP1 and systemic lupus erythematosus: Candidate gene analysis and Genome-wide association studies (GWAS) have shown a significant association of polymorphic variants in the extended promoter and/or coding regions of NLRP1 with familial cases of generalized vitiligo (28, 29), celiac disease (30), Addison’s disease and type 1 diabetes (31, 32), autoimmune thyroid disorders (AITDs) (33), systemic lupus erythematosus (SLE) (34), systemic sclerosis and giant cell arteritis (35, 36), congenital toxoplasmosis (37), rheumatoid arthritis (38), and Alzheimer’s disease (39) (Figure 3).