In a study by Elinav et al., Nlrp6−/− mice showed an altered gut microbiota with an increase in colitogenic bacterial strains such as Prevotellaceae and TM7, which are also found in increased numbers in IBD patients, indicating a role for NLRP6 in the regulatory sensing system in the gut as well (92). Here, NLRP6 is linked to inflammatory bowel disease.