SRF and chronic obstructive pulmonary disease: MiR-1 downregulation is observed in patients with chronic obstructive pulmonary disease (COPD) and is associated with a downregulation of the MRTF-SRF axis (Lewis et al., 2012); an important transcriptional complex regulating muscle gene expression (Cen et al., 2004; Charvet et al., 2006; Miano et al., 2007).