RYR2 and Malignant hyperthermia: Paralogue annotation of variants is widely applicable: approximately half of all disease-associated genes have one or more paralogues with disease-causing variants.10 The technique can also be applied in a reciprocal manner, as illustrated here with RYR1 and RYR2, and our web-based application will be informative for researchers and clinicians interested in a range of diseases mediated by ion channels and membrane excitability, such as malignant hyperthermia and central core disease, and as well as the cardiovascular genetics community.