MMP-1, MMP-3, MMP-7, and MMP-10 gene expression was analyzed by quantitative RT-PCR in M. tuberculosis stimulated PBMCs from 16 TB-IRIS participants treated with prednisone therapy compared with 12 patients who were placebo treated over 4 weeks of prednisone versus placebo treatment. The gene discussed is MMP10; the disease is tuberculosis.