EPAS1 and nonpapillary renal cell carcinoma: Rapamycin, which binds the FKBP-rapamycin-binding domain and not the ATP binding pocket, predominantly inhibits mTORC1 complex formation.51 As recent data have demonstrated that mTORC2 is important for HIF-2α protein translation in ccRCC,31, 32 we asked the question of whether HIF-2α ablation by an mTORC1/2 kinase inhibitor, which interacts with the ATP binding pocket of mTOR and thus inhibits both mTORC1 and mTORC2 activity, affected p53 status in ccRCC cells.