We confirmed that the effects of pp242 on p53 phosphorylation were not due to a nonspecific inhibition of ATM kinase activity as the mTORC1/2 kinase inhibitor had no effect on phosphorylation levels of ATM, whereas it markedly reduced CPT-mediated p53 phosphorylation in ccRCC cell lines (Supplementary Figure 5A). The gene discussed is ATM; the disease is nonpapillary renal cell carcinoma.