However, hypopigmentation may also represent a feature of genetic disorders characterized by immunodeficiency, including Chediak Higashi Syndrome (CHS), Griscelli Syndrome (GS), Hermansky-Pudlak type 2 Syndrome (HPS2) and MAPBPIP-deficiency Syndrome. The gene discussed is LAMTOR2; the disease is Chédiak-Higashi syndrome.