Compared to the base model, the separate addition of MC1R, pigmentation score, nevi, non-melanoma skin cancer and solar lentigines each considerably improved the discriminative ability of the model, whereas inclusion of self-reported sun and sunbed exposure variables (childhood sun exposure, childhood blistering sunburns and lifetime sunbed use) resulted in minimal improvement, and inclusion of family history resulted in no improvement (Table 2). The gene discussed is MC1R; the disease is non-melanoma skin carcinoma.