Multivariate analysis showed that major vascular invasion (HR 2.624, 95% CI 2.149-3.203, P <0.001), tumor size (HR 1.670, 95% CI 1.405-1.986, P <0.001), tumor number (HR 1.569, 95% CI 1.333-1.846, P <0.001), PT (HR 1.424, 95% CI 1.217-1.666, P <0.001), ALB (HR 1.363, 95% CI 1.005-1.848, P = 0.046), PLT (HR 1.287, 95% CI 1.034-1.602, P = 0.024), and AFP (HR 1.179, 95% CI 1.011-1.375, P = 0.035) were significant prognostic factors for OS (Table 4). The gene discussed is AFP; the disease is neoplasm.