Coupling this new continuous variable of Fx (III, IV, or ETS) with the continuous variable of PSA density (PSAD) that we termed as Fx (III, IV, ETS) + PSA density (FPd), a logistic regression model was developed to predict the risk of high-grade cancer (Gleason ≥7) with an overall accuracy of 80% (Table 7). The gene discussed is KLK3; the disease is cancer.