Two signaling pathways, namely Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of Rapamycin (mTOR) pathways, play central roles in many types of tumor cell proliferation, and can lead to aberrant signaling and uncontrolled proliferative diseases [6]. The gene discussed is AKT1; the disease is neoplasm.