Similarly, miR-1 and miR-449a, which could be induced by 5-AzaC/TSA treatment (Datta et al., 2008) or by HDAC1-3 knock down (Buurman et al., 2012) in HCC cells, directly targeted HDAC4 (Chen et al., 2006) and HDAC1 (Noonan et al., 2009), respectively. This evidence concerns the gene HDAC1 and hepatocellular carcinoma.