Indeed, transgenic expression of CagA in mice was recently shown to cause multiple malignancies including gastric epithelial hyperplasia and, in some cases, gastric polyps and adenocarcinomas of the stomach and small intestine, or myeloid leukemias and B cell lymphomas, establishing the role of CagA as a bacterial oncoprotein (35). This evidence concerns the gene S100A8 and B-cell non-Hodgkin lymphoma.