Accordingly, experiments using Teffs transfer from donor mice expressing a Foxp3-reporter indicate that generation of peripherally derived FoxP3+ pTregs out of GFP− Teffs within tumors is inefficient and that tumor-infiltrating GFP+FoxP3+ tTregs are highly stable and do not readily convert back to FoxP3− T-cells contrary to pTregs (89). Here, FOXP3 is linked to neoplasm.