Our findings showed the following: (1) there is a strong and consistent correlation between HGF and the compensatory mechanism from β-cells in three animal models of insulin-resistance; (2) that HGF increases β-cell mass in a dose-dependent manner; (3) blocking HGF shuts down the compensatory mechanisms; and (4) an increase in HGF levels seems to precede the compensatory response associated with insulin-resistance, indicating that these events occur in a causal fashion. Here, HGF is linked to Insulin resistance.