GJA1 and oculodentodigital dysplasia: We start with an overview of connexins and its channels (section Connexin Channels: Gap Junctions and Hemichannels), provide an in depth analysis of the consequence of ODDD mutations on channel function (section ODDD-Linked Mutations and Cx43 Channel Function) and end by examining how channel dysfunction may lead to alterations in neural tissue functioning (section Neurological Phenotype in ODDD—Link to Aberrant Cx43 Channels).